How Terahertz Waves Tear Apart DNA

[Raven]

Friday, October 30, 2009
How Terahertz Waves Tear Apart DNA
A new model of the way the THz waves interact with DNA explains how the damage is done and why evidence has been so hard to gather



Great things are expected of terahertz waves, the radiation that fills the slot in the electromagnetic spectrum between microwaves and the infrared. Terahertz waves pass through non-conducting materials such as clothes , paper, wood and brick and so cameras sensitive to them can peer inside envelopes, into living rooms and "frisk" people at distance.

The way terahertz waves are absorbed and emitted can also be used to determine the chemical composition of a material. And even though they don't travel far inside the body, there is great hope that the waves can be used to spot tumours near the surface of the skin.

With all that potential, it's no wonder that research on terahertz waves has exploded in the last ten years or so.

But what of the health effects of terahertz waves? At first glance, it's easy to dismiss any notion that they can be damaging. Terahertz photons are not energetic enough to break chemical bonds or ionise atoms or molecules, the chief reasons why higher energy photons such as x-rays and UV rays are so bad for us. But could there be another mechanism at work?

The evidence that terahertz radiation damages biological systems is mixed. "Some studies reported significant genetic damage while others, although similar, showed none," say Boian Alexandrov at the Center for Nonlinear Studies at Los Alamos National Laboratory in New Mexico and a few buddies. Now these guys think they know why.

Alexandrov and co have created a model to investigate how THz fields interact with double-stranded DNA and what they've found is remarkable. They say that although the forces generated are tiny, resonant effects allow THz waves to unzip double-stranded DNA, creating bubbles in the double strand that could significantly interfere with processes such as gene expression and DNA replication. That's a jaw dropping conclusion.

And it also explains why the evidence has been so hard to garner. Ordinary resonant effects are not powerful enough to do do this kind of damage but nonlinear resonances can. These nonlinear instabilities are much less likely to form which explains why the character of THz genotoxic
effects are probabilistic rather than deterministic, say the team.

This should set the cat among the pigeons. Of course, terahertz waves are a natural part of environment, just like visible and infrared light. But a new generation of cameras are set to appear that not only record terahertz waves but also bombard us with them. And if our exposure is set to increase, the question that urgently needs answering is what level of terahertz exposure is safe.

Ref: arxiv.org/abs/0910.5294: DNA Breathing Dynamics in the Presence of a Terahertz Field


http://www.technologyreview.com/blog/arxiv/24331/

[Rainchild]

The title is a little misleading since we still don't know all that much about THz feilds

[kashmoney]

From wikipedia: http://en.wikipedia.org/wiki/Terahertz_radiation

Theoretical and technological uses under development

Medical imaging:
Terahertz radiation is non-ionizing, and thus is not expected to damage tissues and DNA, unlike X-rays. Some frequencies of terahertz radiation can penetrate several millimeters of tissue with low water content (e.g. fatty tissue) and reflect back. Terahertz radiation can also detect differences in water content and density of a tissue. Such methods could allow effective detection of epithelial cancer with a safer and less invasive or painful system using imaging.
Some frequencies of terahertz radiation can be used for 3D imaging of teeth and may be more accurate and safer than conventional X-ray imaging in dentistry.

Security:
Terahertz radiation can penetrate fabrics and plastics, so it can be used in surveillance, such as security screening, to uncover concealed weapons on a person, remotely. This is of particular interest because many materials of interest have unique spectral "fingerprints" in the terahertz range. This offers the possibility to combine spectral identification with imaging. Passive detection of Terahertz signatures avoid the bodily privacy concerns of other detection by being targeted to a very specific range of materials and objects.[4]

Scientific use and imaging:
Spectroscopy in terahertz radiation could provide novel information in chemistry and biochemistry.
Recently developed methods of THz time-domain spectroscopy (THz TDS) and THz tomography have been shown to be able to perform measurements on, and obtain images of, samples which are opaque in the visible and near-infrared regions of the spectrum. The utility of THz-TDS is limited when the sample is very thin, or has a low absorbance, since it is very difficult to distinguish changes in the THz pulse caused by the sample from those caused by long term fluctuations in the driving laser source or experiment. However, THz-TDS produces radiation that is both coherent and broadband, so such images can contain far more information than a conventional image formed with a single-frequency source.

A primary use of submillimeter waves in physics is the study of condensed matter in high magnetic fields, since at high fields (over about 15 teslas), the Larmor frequencies are in the submillimeter band. This work is performed at many high-magnetic field laboratories around the world.

Submillimetre astronomy.
Terahertz radiation could let art historians see murals hidden beneath coats of plaster or paint in centuries-old building, without harming the artwork.[5]

Communication:
Potential uses exist in high-altitude telecommunications, above altitudes where water vapor causes signal absorption: aircraft to satellite, or satellite to satellite.

Manufacturing:
Many possible uses of terahertz sensing and imaging are proposed in manufacturing, quality control, and process monitoring. These generally exploit the traits of plastics and cardboard being transparent to terahertz radiation, making it possible to inspect packaged goods.

[Raven]

The title is a little misleading since we still don't know all that much about THz feilds

Not really since they based their conclusions on their model. They also mentioned this effect was probalistic not deterministic. So, It's a fair statement to postulate this would happen.

Alexandrov and co have created a model to investigate how THz fields interact with double-stranded DNA and what they've found is remarkable. They say that although the forces generated are tiny, resonant effects allow THz waves to unzip double-stranded DNA, creating bubbles in the double strand that could significantly interfere with processes such as gene expression and DNA replication. That's a jaw dropping conclusion.

[Rainchild]

I read the whole thing

I'm just saying that it was a little misleading, because it admits at the end that we still don't know what level of exposure is safe. so it could be low exposure or high exposure we don't know yet.

Of course, terahertz waves are a natural part of environment, just like visible and infrared light. But a new generation of cameras are set to appear that not only record terahertz waves but also bombard us with them. And if our exposure is set to increase, the question that urgently needs answering is what level of terahertz exposure is safe.

I don't think it's completely misleading though. I just want to clarify that.

[Raven]

I read the whole thing

I'm just saying that it was a little misleading, because it admits at the end that we still don't know what level of exposure is safe. so it could be low exposure or high exposure we don't know yet.

Of course, terahertz waves are a natural part of environment, just like visible and infrared light. But a new generation of cameras are set to appear that not only record terahertz waves but also bombard us with them. And if our exposure is set to increase, the question that urgently needs answering is what level of terahertz exposure is safe.

I don't think it's completely misleading though. I just want to clarify that.

10/4.